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December 8, 2025BloodOpen Access

Multiomic evidence of coordinated complex rearrangements, enhancer hijacking, and epigenomic signatures in the first whole-chromosome-phased myeloma genomes

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Authors

NBNathan BeckerZSZachary SanbornJHJames E. Hoffman

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Overview

Multiomic analysis identifies structural variations and DNA methylation patterns in myeloma, suggesting intricate genomic interactions.

Key Points

  • Haplotype-resolved assemblies reveal complex structural variations in multiple myeloma genomes.
  • Integration of various data types led to the identification of several structural variations and DNA methylation patterns.
  • Observational analysis employing whole genome sequencing, copy number assessment, and epigenomic profiling.
  • Findings highlight the intricate nature of genomic organization and its implications for myeloma biology.

Cite This Study

Becker et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5fchttps://doi.org/10.1182/blood-2025-3928
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Also Consider

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  1. 1Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma2025
  2. 2Targeted long-read sequencing with adaptive sampling in multiple myeloma: A pilot study toward a unified diagnostic platform2025 · 1 citations
  3. 3Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples2025
  4. 4Sensitive detection of novel structural variants and 3D chromosome conformation reveals likely novel drivers including enhancer hijacking in AML2025
  5. 5On the cellular origins of multiple myeloma2025