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December 8, 2025BloodOpen Access

Subclonal genomic heterogeneity shapes immune crosstalk and clinical outcomes in multiple myeloma

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Authors

SLSihong LiKLKelvin H. LeeRARafat Abonour

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Overview

Analysis reveals subclonal genomic alterations affect immune interactions and progression-free survival in multiple myeloma, suggesting new immunotherapy targets.

Key Points

  • Greater subclonal genomic alterations correlate with worse clinical outcomes, highlighting the complexity of multiple myeloma.
  • Progression-free survival is significantly lower for patients with specific genomic alterations, indicating a need for tailored therapies.
  • Whole genome sequencing provides critical insights into subclone-specific mutations and copy number alterations.
  • Immunotherapy approaches must consider the influence of subclonal diversity on treatment response and clinical outcomes.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6e3https://doi.org/10.1182/blood-2025-5732
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