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December 8, 2025BloodOpen Access

The role of RhoA in diffuse large B-cell lymphoma

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Authors

RKRamesh KrishnanBHBjörn HäuplNDNiklas Dienstbier

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Overview

Observational analysis revealed RhoA mutations regulate B-cell receptor signaling in lymphoma, suggesting new targeted therapy approaches.

Key Points

  • RhoA mutations significantly impact B-cell receptor signaling and cell survival in diffuse large B-cell lymphoma.
  • Critical role defined in promoting oncogenic survival pathways through altered genetic alterations within cell networks.
  • Assessment using proximity ligation assays and quantitative proteomics elucidated mechanisms of BCR micro-clustering effects.
  • This research highlights potential targeted therapy approaches for RhoA-mutated diffuse large B-cell lymphoma cases.

Cite This Study

Krishnan et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1chttps://doi.org/10.1182/blood-2025-5308
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Also Consider

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  1. 1RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis2025
  2. 2Divergent Morphologies and Common Signaling Features of Active and Inactive Oncogenic RHOA Mutants in Yeast2025
  3. 3PAN-CANCER ANALYSES IDENTIFY ONCOGENIC DRIVERS, EXPRESSION SIGNATURES, AND THERAPEUTIC VULNERABILITIES IN RHO GTPase PATHWAY GENES2025
  4. 4RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization2025
  5. 5Inhibition of autoantigen-induced B-cell receptor (BCR) internalization as a therapeutic strategy in Diffuse Large B Cell Lymphoma (DLBCL)2025