September 16, 2025CellsOpen Access

Divergent Morphologies and Common Signaling Features of Active and Inactive Oncogenic RHOA Mutants in Yeast

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Discussion

Experimental analysis reveals distinct phenotypic profiles in RHOA mutants in yeast, suggesting divergent signaling implications.

Gain-of-function and loss-of-function RHOA mutants exhibited distinct morphological clusters, indicating functional divergence.
All investigated RHOA variants conferred myriocin resistance, highlighting activated stress response pathways in yeast.
Using high-dimensional image analysis, 501 morphological parameters were quantified to determine distinct phenotypes.
Our yeast model provides insights into the cellular impacts of oncogenic RHOA mutations and context-dependent mechanisms.

Wang et al. (2025) studied this question.

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