September 19, 2025Open Access

PAN-CANCER ANALYSES IDENTIFY ONCOGENIC DRIVERS, EXPRESSION SIGNATURES, AND THERAPEUTIC VULNERABILITIES IN RHO GTPase PATHWAY GENES

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Discussion

Pan-cancer analysis unveils oncogenic drivers and therapeutic vulnerabilities in RHO GTPase genes, suggesting novel cancer treatment pathways.

New oncogenic drivers were identified in pathways crucial for cancer progression.
The analysis covered 484 RHO GTPase-related genes across over 10,000 tumor samples.
Comprehensive approaches included transcriptomic profiling and functional dependency screens.
Insights may highlight novel therapeutic vulnerabilities in diverse cancers.

Fernández et al. (2025) studied this question.

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Pan-cancer analysis unveils oncogenic drivers and therapeutic vulnerabilities in RHO GTPase genes, suggesting novel cancer treatment pathways.