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December 8, 2025Blood

Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond

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Authors

SCShaun CordobaISIsmael De La Iglesia San SebastiánJTJuan Carlos Triviño

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Overview

Observational analysis identified gene rearrangements in diffuse large B cell lymphoma, suggesting NGS enhances genomic profiling and patient stratification.

Key Points

  • NGS identified gene rearrangements in 37 of 48 lymphoma cases with 59 fusion genes reported.
  • Copy number variations provided critical insights alongside traditional methods like immunohistochemistry.
  • Analysis utilized formalin-fixed paraffin-embedded tumor samples and advanced sequencing technology.
  • Results imply NGS can enhance diagnostic precision and therapeutic guidance in aggressive lymphomas.

Cite This Study

Cordoba et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dae3https://doi.org/10.1182/blood-2025-5310
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical use of genome-wide hi-c sequencing for assessment of structural variants in diffuse large B-cell lymphoma2025
  2. 2Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms2025
  3. 3Multiparametric integration improves diagnostic categorisation of mature, non-CLL B-cell leukemias including atypical CLL - results from the prospective enable-NGS study2025
  4. 4DNA sequencing outperforms RNA sequencing for comprehensive fusion detection in lymphoma diagnostics2025
  5. 5Closing the gap: Genetic profiling of B-cell lymphomas using integrative whole-exome and whole-transcriptome sequencing2025