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December 8, 2025BloodOpen Access

Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms

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Authors

DKDeepika KumarDBDemetrios T. Braddock

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Overview

Observational analysis shows chromosomal aberrations in lymphoid neoplasms, indicating Hi-C sequencing may enhance diagnosis.

Key Points

  • Hi-C sequencing identified cryptic genomic aberrations in lymphoid neoplasms, enhancing diagnostic accuracy.
  • Using Hi-C, we uncovered structural variants in three lymphoma cases, including Burkitt lymphoma and genomic rearrangements.
  • Assessment using chromosome conformation capture revealed ETV6 deletion in a patient with diffuse large B-cell lymphoma.
  • This technique may enable better classification of lymphoid malignancies that are not detected by traditional methods.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e139https://doi.org/10.1182/blood-2025-4355
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hi-C Technology Reveals Actionable Gene Fusions and Rearrangements in Diffuse Large B-Cell Lymphoma Unidentified by Conventional FISH2025 · 2 citations
  2. 2Clinical use of genome-wide hi-c sequencing for assessment of structural variants in diffuse large B-cell lymphoma2025
  3. 3Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond2025 · 1 citations
  4. 4Hi-c FFPE sequencing analysis is highly concordant with FISH and detects additional variants informing diagnosis and treatment in diffuse large B-cell lymphoma2025
  5. 5“In situ” MYC rearrangement and amplification as a secondary change in a case of High-grade B cell lymphoma with 11q aberration2025 · 1 citations