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December 8, 2025BloodOpen Access

Multiparametric integration improves diagnostic categorisation of mature, non-CLL B-cell leukemias including atypical CLL - results from the prospective enable-NGS study

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Authors

KYKyoko YamaguchiENE NashMHMichael Hubank

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Overview

Observational analysis improved diagnostic categorisation in B-cell leukemias, indicating better access to clinical trials and targeted therapies.

Key Points

  • Improved diagnostic categorisation enabled the assignment of categories in 61% of patients with B-cell leukemias, indicating significant clinical impact.
  • At 4-year follow-up, combining clinical presentation and NGS, key diagnoses included marginal zone lymphoma and atypical CLL.
  • Utilizing next-generation sequencing and immunophenotyping, the study categorized difficult-to-diagnose leukemias more accurately than standard methods.
  • This approach suggests potential benefits for patient management and easier access to clinical trials for targeted treatments.

Cite This Study

Yamaguchi et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d97dhttps://doi.org/10.1182/blood-2025-1753
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma2025
  2. 2Closing the gap: Genetic profiling of B-cell lymphomas using integrative whole-exome and whole-transcriptome sequencing2025
  3. 3Combining next-generation sequencing and optical genome mapping techniques to analyze genomic abnormalities in marginal zone lymphoma2025
  4. 4Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond2025 · 1 citations
  5. 5Clinical value of advanced genomic testing in adult Philadelphia-negative B-ALL: Results from the CZ national leukemia study group (CELL)2025