December 8, 2025Blood

DNA sequencing outperforms RNA sequencing for comprehensive fusion detection in lymphoma diagnostics

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Analysis shows DNA sequencing detected 92% of fusion genes in non-Hodgkin lymphoma, indicating its superiority over RNA-sequencing.

DNA sequencing outperformed RNA sequencing by detecting 92% of gene fusions in non-Hodgkin lymphoma cases.
Among 108 NHL patients, only 11 fusion genes were identified by RNA sequencing, revealing its limitations compared to DNA sequencing.
Using targeted DNA-seq and RNA-seq data, we evaluated fusion detection accuracy through comprehensive manual reviews.
Findings support the need for DNA sequencing as a primary method for fusion gene screening in lymphoma diagnostics.

Kun Ru (2025) studied this question.

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December 8, 2025Blood

View Full Paper

Ask AI

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Authors

Analysis shows DNA sequencing detected 92% of fusion genes in non-Hodgkin lymphoma, indicating its superiority over RNA-sequencing.

DNA sequencing outperformed RNA sequencing by detecting 92% of gene fusions in non-Hodgkin lymphoma cases.
Among 108 NHL patients, only 11 fusion genes were identified by RNA sequencing, revealing its limitations compared to DNA sequencing.
Using targeted DNA-seq and RNA-seq data, we evaluated fusion detection accuracy through comprehensive manual reviews.
Findings support the need for DNA sequencing as a primary method for fusion gene screening in lymphoma diagnostics.

Kun Ru (2025) studied this question.

View Full Paper

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Bookmark