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December 8, 2025BloodOpen Access

Functional plasma cell signatures mark AML chemotherapy responders: Evidence from immune niche profiling

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Authors

MYMa YingCGClaire GouldDTDiana O. Treaba

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Overview

Analysis reveals differential gene expression and immune microenvironment differences in AML responders, suggesting B cell role in treatment efficacy.

Key Points

  • Complete response in AML patients correlates with increased immunoglobulin genes, highlighting immune activity.
  • Differential expression analysis shows significance in plasma cell functionality between responders and non-responders.
  • The immune microenvironment differs notably, indicating leukemic stem cells impact chemotherapy outcomes.
  • Findings suggest potential for B cell targeting in therapeutic strategies for improving AML treatment.

Cite This Study

Ying et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da3chttps://doi.org/10.1182/blood-2025-3502
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Also Consider

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  4. 4Comprehensive profiling of the bone marrow microenvironment reveals an exhausted immune signature associated with tumor burden in Acute Myeloid Leukemia2025
  5. 5Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions2025