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December 8, 2025BloodOpen Access

Searching for a myelodysplastic syndrome stem cells (MDS-SCs) signature by flow cytometry: Toward a new prognostic tool?

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Authors

ASAnna SicuranzaMCMariachiara CuccaroASAdele Santoni

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Overview

This analysis reveals acute myeloid leukemia evolution from hematopoietic stem cells in bone marrow.

Key Points

  • Identified LSCs and HSCs in bone marrow correlate with progression to acute myeloid leukemia and risk stratification.
  • Thirty-one percent exhibited mutations indicative of early myelodysplastic syndrome or acute myeloid leukemia features.
  • Flow-cytometry and molecular tests were integrated to evaluate the hematopoietic stem cell compartments of 55 patients.
  • Findings suggest advancements in monitoring myelodysplastic syndromes to improve management and prognosis risk.

Cite This Study

Sicuranza et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da2bhttps://doi.org/10.1182/blood-2025-5615
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell multiomics reveals molecular identities and clonal dynamics of MRD progression in Myelodysplastic Syndromes after stem cell transplant2025
  2. 2Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025
  3. 3Integrating Molecular Alterations with Immunophenotype and Clinical Characteristics in Myelodysplastic Syndromes: A Single-Center Study2025
  4. 4Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression2025
  5. 5MDS without clonal marker: When depth outperforms breadth2025