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December 8, 2025BloodOpen Access

Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression

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Authors

EBEesha BalarSDSafoora DeihimiSLSelina M. Luger

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Overview

Longitudinal analysis reveals somatic mutations in MDS patients influence pathways to myeloid leukemia, suggesting targeted monitoring may improve outcomes.

Key Points

  • Somatic mutations correlated with clonal evolution present challenges in treatment strategies for MDS.
  • Patients undergoing stem cell transplant demonstrate significant clonal evolution changes compared to non-transplant patients.
  • Longitudinal genomic profiling shows TP53 mutations are particularly associated with poor prognosis in MDS.
  • The findings highlight the importance of early detection of epigenetic regulators for personalized treatment options in MDS.

Cite This Study

Balar et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e41ehttps://doi.org/10.1182/blood-2025-5635
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