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September 10, 2025International Journal of Molecular SciencesOpen Access

Integrating Molecular Alterations with Immunophenotype and Clinical Characteristics in Myelodysplastic Syndromes: A Single-Center Study

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Authors

MMMaciej MajcherekKPKrzysztof PrzeorskiAMAleksandra Mroczkowska-Bękarciak

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Overview

Single-center analysis reveals genetic alterations link to immunophenotype in myelodysplastic syndromes, suggesting improved diagnostic strategies.

Key Points

  • Molecular abnormalities correlate with immunophenotype deviations in myelodysplastic syndromes, enhancing diagnostic accuracy.
  • Higher ELN scores were linked to mutations in epigenetic modifiers and tumor suppressor genes in patients with MDS.
  • Next-generation sequencing and multiparametric flow cytometry were utilized to assess genetic alterations and immunophenotype.
  • Investigating these correlations highlights the potential for developing new diagnostic scales for myelodysplastic syndromes.

Cite This Study

Majcherek et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d64790045https://doi.org/10.3390/ijms26157382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integration of Next-Generation Sequencing in Measurable Residual Disease Monitoring in Acute Myeloid Leukemia and Myelodysplastic Neoplasm2025 · 5 citations
  2. 2Longitudinal genomic and cytogenetic dynamics in myelodysplastic syndromes (MDS): Insights into clonal evolution and disease progression2025
  3. 3Searching for a myelodysplastic syndrome stem cells (MDS-SCs) signature by flow cytometry: Toward a new prognostic tool?2025 · 1 citations
  4. 4MDS without clonal marker: When depth outperforms breadth2025
  5. 5Molecular subclusters across the continuum of myelodysplastic neoplasms and acute myeloid leukaemia define distinct clinical entities2025