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December 8, 2025Blood

Single-cell multiomics reveals molecular identities and clonal dynamics of MRD progression in Myelodysplastic Syndromes after stem cell transplant

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Authors

JLJae‐Hyun LeeWLWesley S. LuAVAlejandro Marinos Velarde

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Overview

Single-cell analysis reveals phenotypic and genetic MRD progression in myelodysplastic syndromes post stem cell transplant, indicating immune evasion strategies.

Key Points

  • Significant phenotypic and genetic evolution in MRD post-stem cell transplant highlights clonal dynamics.
  • Using single-cell multiomics, MRD cells were effectively detected and characterized in bone marrow samples.
  • Increased expression of key cytokine signaling pathways in MRD supports immune evasion mechanisms in MDS.
  • Findings suggest a novel perspective on MRD persistence and highlight potential therapeutic targets for myelodysplastic syndromes.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8c1https://doi.org/10.1182/blood-2025-674
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma2026
  2. 2Clinical translation of single cell measurable residual disease (scMRD) assay in real world Acute Myeloid Leukemia (AML) patients2025
  3. 3Measurable residual disease in newly diagnosed multiple myeloma: Experience from a large cohort from an academic medical center2025
  4. 4A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  5. 5Post-induction minimal residual disease assessment by flow cytometry and molecular biology enables prognostic stratification of patients with NPM1-mutated Acute Myeloid Leukemia: A dataml registry study.2025