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December 8, 2025Blood

Beyond complement: Patient and in vitro evidence for alternative mechanisms of Monocyte–Platelet aggregation in PNH

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FRFrederic Ries

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Overview

Analysis shows increased monocyte-platelet aggregation in Paroxysmal nocturnal haemoglobinuria, indicating alternative activation pathways beyond GPI-deficiency.

Key Points

  • Increased platelet aggregation occurs in PNH patients, where monocytes show a median aggregation rate of 16%.
  • Flow cytometric analysis identified the contribution of CD64 and CD14 in monocyte-platelet aggregates.
  • Investigation involved in vitro assays with monocyte cell lines and stimulation with platelet-rich plasma from patients and controls.
  • Findings imply intercellular interactions may enhance platelet aggregation and inform new therapeutic strategies.

Cite This Study

Frederic Ries (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9bahttps://doi.org/10.1182/blood-2025-2988
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of neutrophil extracellular traps in thrombosis of paroxysmal nocturnal hemoglobinuria2025
  2. 2Elucidating gene alterations driving hematopoietic dysfunction in PNH via patient-derived ips cell modeling and whole-genome sequencing2025
  3. 3PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report2025
  4. 4Treatment-requiring paroxysmal nocturnal hemoglobinuria in association with myeloproliferative neoplasms (MPNs): Clinical correlations and outcomes2025
  5. 5Clonal hematopoiesis and immune dysregulation in classic PNH2025