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December 8, 2025BloodOpen Access

The role of neutrophil extracellular traps in thrombosis of paroxysmal nocturnal hemoglobinuria

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Authors

YYYan YangYCYingying Chen

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Overview

Observations reveal neutrophil extracellular traps elevate thrombosis risk in paroxysmal nocturnal hemoglobinuria, indicating potential therapeutic targets.

Key Points

  • This study investigates the role of neutrophil extracellular traps in thrombosis associated with paroxysmal nocturnal hemoglobinuria.
  • 28 PNH patients and 17 healthy controls were enrolled.
  • Plasma NET biomarkers were quantified by ELISA.
  • Circulating neutrophil-platelet aggregates were assessed via flow cytometry.
  • Neutrophils were isolated and stimulated with various agents for NETosis quantification.
  • Thrombotic PNH patients exhibited elevated MPO-DNA and CitH3 levels compared to non-thrombotic patients.
  • Higher circulating neutrophil-platelet aggregates were found in PNH patients versus controls, peaking in thrombotic cases.
  • Optimal NETosis conditions yielded greater eDNA release in PNH neutrophils compared to controls.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d319https://doi.org/10.1182/blood-2025-1112
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