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August 6, 2025Bleeding Thrombosis and Vascular BiologyOpen Access

PO69 | Whole blood thrombin generation hypercoagulable profile in a patient with hemolytic crisis due to paroxysmal nocturnal hemoglobinuria: a case report

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Overview

Case report finds a hypercoagulable profile in a PNH patient, suggesting whole blood thrombin generation may refine thrombotic risk assessment.

Key Points

  • Whole blood thrombin generation test reveals a hypercoagulable state in a patient with paroxysmal nocturnal hemoglobinuria.
  • The patient experienced a hemolytic crisis but showed no thrombotic events during hospitalization.
  • Flow cytometry confirmed a large PNH clone across blood cell types, indicating a severe form of the disease.
  • Using WB-TG provides insights into thrombotic risk, potentially guiding better antithrombotic treatment strategies.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/689521f09f4f1c896c42872dhttps://doi.org/10.4081/btvb.2025.338
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