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December 8, 2025BloodOpen Access

Clonal hematopoiesis and immune dysregulation in classic PNH

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Authors

XQXiaohuan QinXWXuan WangXWXingyu Wang

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Overview

Immune dysregulation impairs HSPC function in classic PNH, suggesting T cell targeting may restore balance.

Key Points

  • Increased T cell proportion correlates with reduced HSPC numbers in classic PNH and aplastic anemia.
  • Single-cell RNA sequencing revealed altered myeloid and lymphoid gene expression in PNH patients.
  • Multiparameter immunophenotyping was conducted on bone marrow samples from classic PNH patients and others.
  • Complement inhibition may alleviate immune activation and stabilize hematopoietic function.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5behttps://doi.org/10.1182/blood-2025-3208
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Also Consider

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  1. 1Elucidating gene alterations driving hematopoietic dysfunction in PNH via patient-derived ips cell modeling and whole-genome sequencing2025
  2. 2Correlation between efficacy, clonal dynamics evolution, and development of bone marrow failure in PNH/AA syndrome treated with complement inhibitors: A single-center cohort study2025
  3. 3Clonal architecture and dynamics of somatic evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria2025 · 1 citations
  4. 4Treatment-requiring paroxysmal nocturnal hemoglobinuria in association with myeloproliferative neoplasms (MPNs): Clinical correlations and outcomes2025
  5. 5Paroxysmal Nocturnal Hemoglobinuria: Unraveling Its Molecular Pathogenesis and Advancing Targeted Therapeutic Strategies2025