Retrospective review of anticoagulation effects on postpartum hemorrhage and VTE in pregnant patients with sickle cell disease, suggesting safety of preventive measures.
Key Points
Evaluate risks of anticoagulation during pregnancy and postpartum in sickle cell disease patients.
Retrospective chart review at Ohio State Wexner Medical Center
Identified pregnant patients using ICD-10 codes
Compared VTE history and anticoagulation outcomes
Applied generalized linear mixed model for categorical variable comparison
Conducted univariate and multivariate analyses for postpartum hemorrhage risk
Identified 75 pregnancies among 59 patients with median age of 28 years
39 pregnancies received anticoagulation with no significant differences in maternal outcomes
VTE episodes occurred primarily with additional provoking factors during pregnancy
Postpartum hemorrhage rates were similar between anticoagulated and non-anticoagulated groups
Anticoagulation linked to 3% rate of heparin-induced thrombocytopenia, no maternal deaths observed
Cite This Study
Roberta C. G. Azbell (2025) studied this question.