Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Interim Results of the CMML scrna-seq atlas: GMP skewing is independently associated with overall survival in CMML.

View Full Paper
Ask AI
Bookmark
Share

Authors

MBMaria E. BalasisSMSean MurphyNDNathalie Droin

Discussion

Loading...

Member takes

Overview

Interim analysis shows gene expression shifts predict survival in chronic myelomonocytic leukemia, suggesting a new prognostic model.

Key Points

  • Survival is linked to specific gene expression patterns in chronic myelomonocytic leukemia.
  • Over 113 patient samples were analyzed using single cell RNA-sequencing.
  • Cox regression was employed to evaluate the relationship between bone marrow composition and survival.
  • This work is a significant step towards developing a comprehensive prognostic model for chronic myeloid neoplasms.

Cite This Study

Balasis et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d858https://doi.org/10.1182/blood-2025-3840
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia via single-cell transcriptome sequencing2025
  2. 2Peripheral blood-based single-cell and genomic profiling of hematopoietic stem and progenitor cells enables accurate diagnosis and risk stratification in myeloproliferative neoplasms2025
  3. 3Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia2025
  4. 4Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions2025
  5. 5Maturing progenitor-like immunophenotypic cluster and megakaryocytic repopulating ability predict measurable residual disease in Acute Myeloid Leukemia2025