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December 8, 2025BloodOpen Access

Exploring molecular heterogeneity and clonal evolution in chronic myelomonocytic leukemia via single-cell transcriptome sequencing

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Authors

JZJie ZhouHWHao WuALAibin Liang

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Overview

Single-cell transcriptome sequencing identifies distinct cellular clusters in chronic myelomonocytic leukemia, suggesting potential therapeutic targets.

Key Points

  • Clonal evolution features were delineated in chronic myelomonocytic leukemia, revealing disease-specific transcriptional characteristics.
  • A total of 1,866 differentially expressed genes were found in patients, highlighting clonal complexity.
  • Bone marrow aspirates underwent single-cell transcriptome sequencing, providing insights into cellular heterogeneity.
  • These findings may inform the development of targeted therapies for chronic myelomonocytic leukemia.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4f3https://doi.org/10.1182/blood-2025-6763
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