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December 8, 2025Blood

Single-cell chromatin profiling reveals early epigenetic reprogramming, subtype-specific regulatory networks, and JAK/STAT–IRF vulnerabilities in high-risk chronic myeloid leukemia

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Authors

BCBeiJun ChenYLYan Ping LimCCCharles Chuah

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Overview

Single-cell analysis uncovers JAK/STAT-IRF vulnerabilities in chronic myeloid leukemia, suggesting new therapeutic strategies.

Key Points

  • This study aims to identify epigenetic changes in chronic myeloid leukemia that lead to drug resistance.
  • Performed single-cell multi-omic profiling on bone marrow mononuclear cells from N=24 chronic myeloid leukemia patients and controls.
  • Analyzed differentially accessible regions and transcription factor activity using advanced genomic techniques.
  • Reconstructed gene regulatory networks to understand signaling pathways involved in resistance.
  • Identified a shared CML-specific epigenetic state distinct from normal hematopoietic stem cells.
  • Found that JAK/STAT and IRF pathways are critical for sustaining drug-resistant stem and progenitor cells.
  • Discovered that JAK inhibition sensitizes blast crisis cells to traditional therapies while sparing normal progenitors.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d102https://doi.org/10.1182/blood-2025-5012
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Also Consider

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  1. 1A single-cell atlas of diagnostic bone marrow to uncover the origins of CML relapse following therapy cessation2025
  2. 2GENETIC ASPECTS OF CHRONIC MYELOID LEUKEMIA: FROM FUNDAMENTAL MECHANISMS TO CLINICAL PRACTICE2025
  3. 3Acquisition of CLL-like epigenetic and transcriptomic states in low-count MBL2025
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  5. 5Systematic molecular profiling to identify determinants of response to ibrutinib2025