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December 8, 2025BloodOpen Access

Longitudinal single-cell profiling in canine DLBCL reveals regulatory networks driving chemotherapy resistance.

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Authors

MBMarjorie BrandXPXuan Pan

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Overview

Longitudinal single-cell profiling reveals transcription factors and immune evasion mechanisms driving treatment resistance in canine DLBCL.

Key Points

  • Therapy-resistant cells expanded at relapse, indicating unique tumor evolution mechanisms.
  • Single-cell analysis uncovered specific transcription factors linked to cancer stem-like properties.
  • Observational analysis using longitudinal samples from canine DLBCL identified novel cellular dynamics.
  • These findings suggest canine models can inform human DLBCL therapies by exploring treatment resistance.

Cite This Study

Brand et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d770https://doi.org/10.1182/blood-2025-1788
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune profiling of canine B cell lymphoma reveals cross-species conservation of prognostic markers2025
  2. 2Peripheral Blood Mononuclear Cell Gene Expression Signatures Predict Long-term Survivorship in Canine DLBCL2025
  3. 3Multimodal profiling identifies CD4+CXCR5+PD-1– Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma2025
  4. 4Multi-omic analysis of early minimal residual disease identifies functional and transcriptomic signatures of treatment resistance in pediatric B-cell acute lymphoblastic leukemia2025
  5. 5Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma2025