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September 20, 2025Chinese Medical JournalOpen Access

Multimodal profiling identifies CD4+CXCR5+PD-1– Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma

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Authors

SYSisi YuHKHao KongHLHuaichao Luo

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Overview

This research explores CD4+ Tfh cells as a predictive biomarker in diffuse large B-cell lymphoma, indicating their role in treatment response.

Key Points

  • CD4+CXCR5+PD-1– Tfh cells are linked to better prognosis in patients with diffuse large B-cell lymphoma.
  • A high score of CD4+ Tfh cells correlates with improved survival rates after R-CHOP treatment.
  • Single-cell RNA sequencing revealed significant insights into the microenvironment of the tumor.
  • The study establishes a model for predicting imaging outcomes to aid in assessing CD4+ Tfh cell presence.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79d2bhttps://doi.org/10.1097/cm9.0000000000003826
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  4. 4Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma2025
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