September 5, 2025Advanced ScienceOpen Access

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage‐Derived Stem Cells

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Co-transplantation of costal cartilage-derived stem cells with multipotent progenitors led to significant recovery in lethally irradiated mice.
Transplantation of mesenchymal stem cells or multipotent progenitors alone failed to rescue the irradiated mice.
RNA-seq and experimental findings indicate that costal cartilage-derived stem cells rejuvenate the bone marrow niche effectively.
These stem cells enhance hematopoietic recovery and protect against radiation-induced damage in a model of aplastic anemia.

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Co-transplantation of costal cartilage-derived stem cells rejuvenates the bone marrow niche, indicating potential for hematopoietic recovery.

Dong et al. (2025) studied this question.

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Co-transplantation of costal cartilage-derived stem cells rejuvenates the bone marrow niche, indicating potential for hematopoietic recovery.