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December 8, 2025BloodOpen Access

Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT

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Authors

MNMaud NgoyaAKAlexander KulaginGHGrzegorz Helbig

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Overview

Analysis shows comparable survival outcomes in T-ALL patients receiving transplant from haploidentical or unrelated donors, indicating viable alternatives to sibling donors.

Key Points

  • Patients receiving transplantation from unrelated and haploidentical donors displayed similar overall outcomes for survival and progression-free measures.
  • Cytomegalovirus seropositivity in recipients correlated with a higher risk of developing graft-versus-host disease and chronic complications.
  • This assessment involves adult T-ALL patients in second remission, categorized by donor type to evaluate post-transplant outcomes effectively.
  • Findings support the use of haploidentical and unrelated donors, enhancing donor options for allogeneic hematopoietic cell transplantation.

Cite This Study

Ngoya et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d47fhttps://doi.org/10.1182/blood-2025-2526
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  2. 2Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  3. 3Similar Outcome With Haploidentical, Matched Sibling, or Matched Unrelated Donor Hematopoietic Cell Transplantation for Adult Patients With Adverse‐Risk <i>TP53</i>‐Mutated Acute Myeloid Leukemia in First Remission: A Comparative Study From the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2025 · 1 citations
  4. 4Selection of unrelated donors for allogeneic transplantation using post-transplant cyclophosphamide in acute lymphoblastic leukemia: An analysis by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2025
  5. 5T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025