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December 8, 2025Blood

Healthcare inequities in Latin America outweigh the benefits of pediatric regimens in adult acute lymphoblastic leukemia

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Authors

WSWellington F SilvaMEMarcela EspinozaEAEdgar Zapata Avila

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Overview

Retrospective cohort analysis shows poorer survival in adults with ALL due to socioeconomic factors and treatment disparities in Latin America.

Key Points

  • Overall survival for adults with ALL in public centers was significantly lower at 34.9% compared to 51.6% in private institutions.
  • Patients treated with dasatinib had a related hazard ratio of 0.544, suggesting a stronger association with better outcomes.
  • Analysis included data from 578 patients newly diagnosed with ALL from 7 centers in Brazil and 13 in Chile.
  • Impacts of socioeconomic factors on adult ALL outcomes emphasize the need for improved treatment strategies in public healthcare.

Cite This Study

Silva et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6f4https://doi.org/10.1182/blood-2025-288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world outcomes and disparities of ph+ ALL in a Latino population2025
  2. 2Effect of Adults and Pediatric-inspired Schemes on Negative Measurable Residual Disease and Overall Survival in Adults with Acute Lymphoblastic Leukemia: A Retrospective Analysis from the Hematology Department at Hospital Regional de Alta Especialidad de Ixtapaluca, Mexico2025
  3. 3Overall survival in patients with acute lymphoblastic leukemia in the aya population, treated with modified pediatric chemotherapeutic schemes, a real-life study2025
  4. 4Real-world treatment and outcomes of Mantle Cell Lymphoma in Latin America: A multinational cohort analysis2025
  5. 5Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025