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December 8, 2025BloodOpen Access

Overall survival in patients with acute lymphoblastic leukemia in the aya population, treated with modified pediatric chemotherapeutic schemes, a real-life study

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Authors

SSSilvia-María Sandoval-CamposLALuara-Luz Arana-lunaJAJose Alvarez

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Overview

Historical cohort analysis finds a 3-year survival rate of 32.5% in adolescents and young adults with Acute lymphoblastic leukemia, suggesting modified protocols improve outcomes.

Key Points

  • Survival rate improved with modified pediatric chemotherapy regimens targeting AYA patients.
  • Complete remission achieved in over 90% of cases using the LALÍN institutional regimen.
  • Analysis of 143 patient records from 2017 to 2023 provided key insights into treatment efficacy.
  • Induction response as a strong predictor of overall survival emphasizes the need for tailored therapy.

Cite This Study

Sandoval-Campos et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236decbhttps://doi.org/10.1182/blood-2025-6844
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world data of adolescents and young adults with acute lymphoblastic leukemia treated with a modified GMALL protocol in India: Treatment outcomes and challenges2025
  2. 2Effect of Adults and Pediatric-inspired Schemes on Negative Measurable Residual Disease and Overall Survival in Adults with Acute Lymphoblastic Leukemia: A Retrospective Analysis from the Hematology Department at Hospital Regional de Alta Especialidad de Ixtapaluca, Mexico2025
  3. 3Outcomes of Adolescents and Young Adults with AML Treated on Pediatric vs Adult Protocols2026
  4. 4Improved outcomes in elderly patients with acute lymphoblastic leukaemia using a paediatric‐based protocol—A prospective study2025
  5. 5T-cell acute lymphoblastic leukemia: therapeutic outcomes in adolescents and young adults2025 · 2 citations