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December 8, 2025BloodOpen Access

At-211-anti-CD45 radioimmunotherapy as conditioning prior to haploidentical hematopoietic cell transplantation in mouse models

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Authors

DHDonald K. Hamlin

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Overview

Observational analysis indicates radioimmunotherapy improves engraftment in mice post-haploidentical transplantation, suggesting reduced toxicity.

Key Points

  • Optimal 211At-anti-CD45 radioimmunotherapy leads to comparable donor-origin chimerism levels to traditional TBI approaches.
  • Mice receiving 30 µCi of 211At-anti-CD45 RIT with pre-CY achieve approximately 56.54% chimerism at day 28 after HCT.
  • Assessment using multicolor flow cytometry measured lineage-specific donor-origin chimerism over time post-transplant.
  • This method may facilitate effective donor engraftment without the typical toxicity associated with TBI or multi-agent chemotherapy.

Cite This Study

Donald K. Hamlin (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6dfhttps://doi.org/10.1182/blood-2025-5866
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  5. 5Non-genotoxic conditioning to increase donor chimerism levels in a mismatched murine transplant model for sickle cell disease2025