Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Non-genotoxic conditioning to increase donor chimerism levels in a mismatched murine transplant model for sickle cell disease

View Full Paper
Ask AI
Bookmark
Share

Authors

AIAyotimofe IdowuMAMohamed AhmedCFCourtney D. Fitzhugh

Discussion

Loading...

Member takes

Overview

Observational analysis improved donor chimerism levels in SCD mouse model using CD117 and Saporin, implying effective conditioning alternatives.

Key Points

  • Chimerism levels increased significantly with CD117 and Saporin conditioning amidst sickle cell disease.
  • Blood analysis revealed enhanced hematopoietic stem cells and normal hemoglobin restoration post-therapy.
  • Mouse model studies indicated CD117 outperformed traditional conditioning methods like TBI in chimerism achievement.
  • Improved interventions could enhance transplant success rates in SCD patients with donor match difficulties.

Cite This Study

Idowu et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d68ehttps://doi.org/10.1182/blood-2025-5858
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining therapeutic chimerism thresholds for comprehensive sickle cell disease correction in the townes mouse model2025
  2. 2Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy2025
  3. 3Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation2025
  4. 4Motixafortide (CXCR4 inhibition) alone and in combination with natalizumab (VLA-4 inhibition) to mobilize hematopoietic stem cells for gene therapy in sickle cell disease: A first-in-human, safety and feasibility study2025 · 1 citations
  5. 5At-211-anti-CD45 radioimmunotherapy as conditioning prior to haploidentical hematopoietic cell transplantation in mouse models2025