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December 8, 2025Blood

Lattice light-sheet microscopy reveals patient specific responses to CD20-directed antibodies in B cell malignancies

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Authors

PEPatrick EiringSHSeungbin HanMSMax Steinhardt

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Overview

Lattice light-sheet microscopy reveals treatment response differences in B cell malignancies, suggesting patient-specific implications for immunotherapy.

Key Points

  • Significant differences in treatment response were observed among antibodies, particularly notable in actin dynamics.
  • Raji cells treated with rituximab showed the highest C1q binding, while ofatumumab maintained stable protrusion lengths.
  • Analysis involved imaging Raji cells and primary B cells from CLL patients using lattice light-sheet microscopy.
  • Personalization of immunotherapy may be enhanced by integrating findings with molecular profiling of individual patients.

Cite This Study

Eiring et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d670https://doi.org/10.1182/blood-2025-4343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytotoxic CD8⁺ T cells are required for CD20xCD3 bispecific antibody-mediated tumor control in B-cell non-Hodgkin lymphomas2025
  2. 2Genomic and immune determinants of response to CD3 x CD20 bispecific antibodies in aggressive B-cell lymphoma2025
  3. 3Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen-specific T cell activation that is superior to membrane IgM delivery2025
  4. 4Uncovering bispecific antibody mechanisms via 3D superresolution imaging of T cell-tumor cell membrane contacts2025
  5. 5Low-intensity focused ultrasound with microbubbles enhances CD20 monoclonal antibody delivery across the blood-brain barrier in primary central nervous system lymphoma2025