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December 8, 2025BloodOpen Access

Genomic and immune determinants of response to CD3 x CD20 bispecific antibodies in aggressive B-cell lymphoma

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Authors

XYXi YangAPAnamarija M. PerryYKYasmin Karimi

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Overview

Analysis reveals mutations and tumor microenvironment factors predicting complete response in aggressive B-cell lymphoma, indicating potential biomarkers for therapy selection.

Key Points

  • To identify genomic and immune determinants of response to CD3 x CD20 bispecific antibodies in aggressive B-cell lymphoma.
  • Performed whole exome sequencing on 15 patients and whole transcriptome sequencing on 15 patients.
  • Analyzed genomic data using Burrows-Wheeler Aligner, VarScan, ANNOVAR, STAR, and HTSeq.
  • Utilized CIBERSORTx and gene set enrichment analysis to evaluate tumor microenvironment.
  • 15 patients included, with a complete response rate of 26.7% to bispecific antibodies.
  • Common mutations included TP53 (53.3%), KMT2D (40%), and CREBBP (33.3%).
  • Higher total T cell levels in GCB hot tumors compared to GCB cold and ABC cold, suggesting a favorable immune microenvironment.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d0d0https://doi.org/10.1182/blood-2025-3542
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