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December 8, 2025Blood

Foreign antigen delivered to CLL B cells via membrane IgD leads to a distinct antigen processing pathway that allows antigen-specific T cell activation that is superior to membrane IgM delivery

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Authors

MCMartina CardilloMFMatthew J. FriedmanXYXiao‐Jie Yan

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Overview

Antigen processing pathway shows superior T cell activation in CLL B cells using IgD over IgM.

Key Points

  • Antigen processing pathway enhances T cell activation driven by IgD in CLL B cells.
  • Higher T cell activation observed with IgD-bound antigen in 16 patients, especially among CD8+ T cells.
  • Assessment using monoclonal antibodies targeting IgM and IgD reveals distinct internalization patterns.
  • Findings suggest an advantage of exploiting IgD-driven processes for immune response in CLL.

Cite This Study

Cardillo et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d867https://doi.org/10.1182/blood-2025-3882
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