Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Low-intensity focused ultrasound with microbubbles enhances CD20 monoclonal antibody delivery across the blood-brain barrier in primary central nervous system lymphoma

View Full Paper
Ask AI
Bookmark
Share

Authors

JHJuan HuangJHJiawen HuangZWZhe Wu

Discussion

Loading...

Member takes

Overview

Preclinical models demonstrate LIFU combined with microbubbles significantly improves rituximab delivery, indicating enhanced therapeutic efficacy for PCNSL.

Key Points

  • The aim is to enhance CD20 monoclonal antibody delivery across the blood-brain barrier using low-intensity focused ultrasound.
  • Established PCNSL model in BALB/c mice
  • Randomized tumor-bearing mice into four treatment groups
  • Applied LIFU with microbubbles to facilitate BBB opening
  • Monitored tumor progression with bioluminescence imaging
  • Analyzed CSF rituximab concentration and tumor volume post-treatment.
  • LIFU with microbubbles significantly increased CD20 mAb delivery with 81.3% tumor reduction
  • Control group showed rapid tumor growth and high mortality
  • CSF rituximab levels were considerably higher in the treatment group
  • Histopathological analyses showed no permanent BBB damage.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d27dhttps://doi.org/10.1182/blood-2025-1793
View Full Paper
Ask AI
Bookmark
Share