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December 8, 2025Blood

Impact of pre-transplant bone marrow cellularity and fibrosis on post-transplant outcomes in sickle cell disease

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Authors

CFCourtney D. Fitzhugh

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Overview

Retrospective study reveals that pre-transplant bone marrow cellularity and fibrosis do not significantly affect outcomes in sickle cell disease patients undergoing HCT, suggesting other factors maybe

Key Points

  • Outcomes showed no significant association with baseline bone marrow cellularity or fibrosis in patients with sickle cell disease undergoing transplantation.
  • Among 39 patients analyzed, 22 (56.4%) exhibited sustained engraftment regardless of cellularity or fibrosis scores.
  • This observational analysis examined pre-transplant bone marrow characteristics in relation to post-transplant graft rejection and clonal hematopoiesis.
  • These findings imply the need for further research to understand the mechanisms underlying transplant outcomes in sickle cell disease patients.

Cite This Study

Courtney D. Fitzhugh (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d612https://doi.org/10.1182/blood-2025-4304
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of hematopoietic cell transplantation on sickle cell hepatopathy and vice versa2025
  2. 2Screening for clonal hematopoiesis in patients with β-hemoglobinopathies who are candidates to transplant approaches2025 · 1 citations
  3. 3Assessment of red blood cell functional biomarkers following hematopoietic cell transplantation in sickle cell disease patients2025
  4. 4Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation2025
  5. 5Longterm survival and late effects following hematopoietic cell transplantation for sickle cell disease into a modern era: A center for international blood and marrow transplant research (CIBMTR) analysis2025 · 2 citations