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December 8, 2025BloodOpen Access

The impact of hematopoietic cell transplantation on sickle cell hepatopathy and vice versa

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Authors

AWAmanda WalkerCFCourtney D. Fitzhugh

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Overview

Retrospective review shows improved liver disease in sickle cell patients post-hematopoietic cell transplantation, indicating safe hepatopathy management.

Key Points

  • Overall survival rate at 1 year reached 100% for patients undergoing hematopoietic cell transplantation.
  • Notably, 66.6% of patients with pre-HCT fibrosis showed stability or improvement in their scores after treatment.
  • Assessment employed included both biochemical markers such as ferritin and direct bilirubin, and histological evaluations for liver disease.
  • Results suggest non-myeloablative HCT may stabilize liver disease in individuals with sickle cell hepatopathy.

Cite This Study

Walker et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd0ehttps://doi.org/10.1182/blood-2025-7839
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of pre-transplant bone marrow cellularity and fibrosis on post-transplant outcomes in sickle cell disease2025
  2. 2Longterm survival and late effects following hematopoietic cell transplantation for sickle cell disease into a modern era: A center for international blood and marrow transplant research (CIBMTR) analysis2025 · 2 citations
  3. 3Encouraging Outcomes of Hematopoeitic Stem Cell Transplantation in Pediatric Sickle Cell Disease- A Decade-Long Experience from the Developing World2025
  4. 4Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells.2025 · 1 citations
  5. 5Assessment of red blood cell functional biomarkers following hematopoietic cell transplantation in sickle cell disease patients2025