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December 8, 2025BloodOpen Access

On the cellular origins of multiple myeloma

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Authors

DZDi ZhangMBMarc BraunsteinNKNeha Korde

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Overview

Analysis uncovers clonal evolution in multiple myeloma, implicating stem cells and mutations in disease progression.

Key Points

  • Multiple myeloma originates from clonal events across hematopoietic development, revealing its complexity.
  • Whole-genome sequencing detected 43% of cases with canonical translocations associated with MM pathogenesis.
  • Hemoglobin variants and mutations across compartments implicate ongoing clonal evolution in disease persistence.
  • Clonal hematopoiesis' role highlights potential therapeutic targets for multiple myeloma treatment strategies.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3e4https://doi.org/10.1182/blood-2025-5694
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic Insights into Tumorigenesis in Newly Diagnosed Multiple Myeloma2025
  2. 2Phylogenetic reconstruction reveals early divergence and late expansion of focal lesions in multiple myeloma2025
  3. 3Single-cell DNA profiling unveils clonal evolution and identifies mechanisms of therapeutic resistance and progression in monoclonal gammopathies2025 · 1 citations
  4. 4Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma2025
  5. 5Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin2025