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December 8, 2025Blood

Accelerated immune aging after induction therapy in multiple myeloma revealed by donor-referenced immune age modeling

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Accelerated immune aging occurs in multiple myeloma patients following induction therapy—particularly in naïve T cells.
The median immune age gap is approximately +15 to +18 years compared to healthy donors.
Immunophenotyping and generalized additive models were used to quantify immune aging in patients and donors.
These findings highlight the need for future studies on strategies to mitigate immune aging effects in therapy.

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Implication

Observational analysis revealed immune age gap in multiple myeloma patients post-therapy, suggesting implications for immune memory and treatment responses.

Cite This Study

Malek et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5fb https://doi.org/10.1182/blood-2025-3935

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Implication

Observational analysis revealed immune age gap in multiple myeloma patients post-therapy, suggesting implications for immune memory and treatment responses.

Accelerated immune aging after induction therapy in multiple myeloma revealed by donor-referenced immune age modeling

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Discussion

Implication

Cite This Study

Accelerated immune aging after induction therapy in multiple myeloma revealed by donor-referenced immune age modeling

Key Points

Discussion

Implication

Cite This Study

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