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December 8, 2025BloodOpen Access

Immune biomarkers of increased risk of infection in multiple myeloma (MM)

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Authors

AZAintzane ZabaletaMMMichaela MachuPBPanagiotis Bakouros

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Overview

Analysis reveals immune biomarkers associated with increased infection risk in multiple myeloma, suggesting new strategies for monitoring.

Key Points

  • Infection risk nearly doubled among patients with multiple myeloma across disease stages, reaching 54% in RRMM.
  • Monocyte and T-cell ratios were significantly different as disease advanced, highlighting immune dysregulation.
  • Cell-type distribution analysis performed on 1,958 samples from multiple myeloma patients and healthy adults.
  • Findings suggest that immune profiles may serve as predictive markers for infection risk in multiple myeloma.

Cite This Study

Zabaleta et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0d6https://doi.org/10.1182/blood-2025-365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Incidence and risk factors for infections in the real-world setting in newly diagnosed myeloma patients treated with modern induction regimens2025
  2. 2Infection rates and mortality in multiple myeloma: Impact of blood counts and IgG levels over time2025
  3. 3An immune proteomic atlas of 300 million bone marrow cells reveals prognostic cell states in multiple myeloma2025
  4. 4Dissecting the multiple myeloma survival niche to improve novel treatment strategies2025
  5. 5Combinations of high risk cytogenetic events in multiple myeloma drive distinct immune remodeling patterns and worse outcomes2025