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December 8, 2025BloodOpen Access

Immune aging and macrophage inhibitory factor (MIF) – mediated stromal rewiring drives pre-malignant evolution in smoldering multiple myeloma

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Authors

RSRajib ShomeDCDiana CirsteaFRFarah Rexha

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Overview

Single-cell RNA sequencing reveals MIF signaling enhances immune dysfunction in smoldering multiple myeloma, impacting progression.

Key Points

  • Immune dysfunction increases in smoldering multiple myeloma, with significant exhaustion in T cells, B cells, and NK cells.
  • Increased macrophage polarization is observed, with MIF signaling enabling interactions in the bone marrow microenvironment.
  • Single-cell RNA sequencing was employed to analyze over 125 samples, revealing key changes across patient and control groups.
  • Findings highlight tumor microenvironment remodeling as a critical aspect in the evolution of smoldering multiple myeloma.

Cite This Study

Shome et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3c6https://doi.org/10.1182/blood-2025-3952
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