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December 8, 2025BloodOpen Access

Burden and trends of sickle cell disease in the United States: Insights from the global burden of disease study 2021

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Authors

SMSameer Kumar MajetyMHMegha Sasidhar HandralRNRithish Nimmagadda

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Overview

Analysis reveals decreasing prevalence and mortality in sickle cell disease, highlighting the need for improved health literacy and treatment adherence.

Key Points

  • The sickle cell disease burden shows a declining trend in prevalence and mortality across the United States, indicating potential improvements in disease management.
  • The age-standardized disability-adjusted life years rate demonstrates a decrease over time, with significant disparities by state and demographic factors.
  • Observational analysis across various states highlights the geographic variation in sickle cell disease prevalence, especially in southern regions.
  • Targeted interventions are necessary to address health literacy and access to treatments like stem cell transplantation for those affected by sickle cell disease.

Cite This Study

Majety et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d53dhttps://doi.org/10.1182/blood-2025-6227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sickle cell disease in the global south: Mapping the unmet burden using global burden of disease DALY estimates and its relevance to United States hematologists2025
  2. 2Disparities in sickle cell disease related mortality in the US-Mexico border region from 1999 to 2020: A CDC wonder Study2025
  3. 3Paradoxical urban mortality penalty in sickle cell disease: A 20-year national analysis revealing age-dependent disparities2025
  4. 4Improvement of sickle cell disease care mitigates the healthcare utilization induced by increased prevalence: Experience of a tertiary pediatric center2025
  5. 5Geographic and temporal trends in sickle cell disease hospitalizations in New York State2025