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December 8, 2025Blood

Disparities in sickle cell disease related mortality in the US-Mexico border region from 1999 to 2020: A CDC wonder Study

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Authors

KAKumail Mustafa AliACAsfand Yar CheemaMIMuhammad Ibrahim

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Overview

Analysis shows increasing sickle cell disease mortality rates in the US-Mexico Border region, highlighting demographic disparities.

Key Points

  • To analyze trends and sociodemographic factors in sickle cell disease-related mortality from 1999 to 2020.
  • Utilized CDC WONDER database for mortality data on sickle cell disease.
  • Identified mortality using ICD-10 codes for various sickle-cell disorders.
  • Calculated age-adjusted mortality rates and annual percent changes using regression analysis.
  • Stratified data by demographic and geographic subgroups.
  • Total of 17,711 deaths from sickle cell disease reported from 1999-2020.
  • Overall age-adjusted mortality rate increased from 2.7 in 1999 to 3.12 in 2020.
  • Non-Hispanic Black population had the highest mortality rate of 19.9 per 100,000 people.
  • Analysis revealed significant variations in mortality rates by age and region.

Cite This Study

Ali et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236d019https://doi.org/10.1182/blood-2025-7974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Paradoxical urban mortality penalty in sickle cell disease: A 20-year national analysis revealing age-dependent disparities2025
  2. 2Burden and trends of sickle cell disease in the United States: Insights from the global burden of disease study 20212025
  3. 3Disparities in autoimmune hemolytic Anemia–Related mortality in the u.S.–Mexico border region, 1999–2020: A CDC wonder study.2025
  4. 4Demographics and Trends of Sudden Cardiac Death‐Related Mortality in the United States, 1999 to 20222025 · 8 citations
  5. 5Analysis of seasonal variation of sickle cell disease with crisis and associated complication in the United States from 2011 to 2019.2025