Sickle cell disease in the global south: Mapping the unmet burden using global burden of disease DALY estimates and its relevance to United States hematologists
Observational analysis reveals rising sickle cell disease prevalence in sub-Saharan Africa, suggesting urgent need for increased newborn screening and equitable access to therapies.
Key Points
Sickle cell disease prevalence increased by 41% globally from 2000 to 2021, particularly affecting sub-Saharan Africa.
In 2021, sub-Saharan Africa accounted for 75-80% of global disability-adjusted life years for sickle cell disease.
Assessment using disability-adjusted life years demonstrates significant mortality disparities in high-burden regions, especially for under-five children.
Highlights the urgent necessity for improved health interventions and equitable access to care for sickle cell disease patients in low-income countries.