December 8, 2025BloodOpen Access

Phylogenetic reconstruction reveals early divergence and late expansion of focal lesions in multiple myeloma

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Phylogenetic reconstruction reveals multiple myeloma subclonal evolution in bone marrow, implying late emergence of focal lesions.

Distinct subclones in multiple myeloma bone marrow show early divergence with focal lesions emerging later.
Median of 3 subclones identified per patient; additional mutations in focal lesions indicate recent clonal expansion.
Phylogenetic trees reveal that subclonal evolution triggers focal lesions shortly before diagnosis in multiple myeloma.
The long-term presence of certain mutations in precursor states hints at their role in poor prognosis and early disease development.

Maclachlan et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

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Authors

Phylogenetic reconstruction reveals multiple myeloma subclonal evolution in bone marrow, implying late emergence of focal lesions.

Distinct subclones in multiple myeloma bone marrow show early divergence with focal lesions emerging later.
Median of 3 subclones identified per patient; additional mutations in focal lesions indicate recent clonal expansion.
Phylogenetic trees reveal that subclonal evolution triggers focal lesions shortly before diagnosis in multiple myeloma.
The long-term presence of certain mutations in precursor states hints at their role in poor prognosis and early disease development.

Maclachlan et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark