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December 8, 2025BloodOpen Access

Diagnosis and prediction of precursor states in multiple myeloma using cell-free chromatin

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Authors

NVNoa VilkEHEsther HarpenasJGJenia Gutin

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Overview

Observational analysis improved risk stratification accuracy in pre-MM individuals, indicating cfChIP-seq may aid in diagnosis.

Key Points

  • MM score showed significant differentiation between healthy individuals and pre-MM stages, indicating its potential in clinical diagnostics.
  • AUC of 0.71 for MM-P subscore identifies pre-MM patients at higher risk of biochemical progression compared to traditional models.
  • Analysis used chromatin immunoprecipitation, providing a non-invasive approach to monitor disease progression in multiple myeloma.
  • Findings suggest increased erythropoiesis in pre-MM stages, highlighting new avenues for personalized medicine in plasma cell disorders.

Cite This Study

Vilk et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d38bhttps://doi.org/10.1182/blood-2025-3948
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the plasma proteome of multiple myeloma and its precursor conditions and identification of a prognostic high-risk signature of progression2025
  2. 2Characterizing circulating rare cells in peripheral blood for detecting and monitoring multiple myeloma and precursor states2025
  3. 3Pre-diagnostic biomarkers show disease susceptibility continuum and enable early prediction of multiple myeloma2025 · 1 citations
  4. 4Liquid biopsy for non-invasive molecular characterization and measurable residual disease analysis in multiple myeloma2025
  5. 5Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples2025