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December 8, 2025BloodOpen Access

Proportion of second hematologic malignancies linked to radiotherapy treatment in adults: A cohort study in the US SEER cancer registries 2001-2022

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ASAbhay Singh

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Overview

Population-based cohort study shows 1.3% of second hematologic malignancies are tied to radiotherapy in cancer patients, suggesting genetic or lifestyle factors play major roles.

Key Points

  • 1.3% of second hematologic malignancies were linked to radiotherapy treatment for first cancers.
  • The most common second hematologic malignancy observed was non-Hodgkin lymphoma, followed by multiple myeloma.
  • Population-based cohort study analyzed data from 2.2 million cancer patients across 17 U.S. registries.
  • Findings suggest most second cancers may arise from other risk factors rather than radiotherapy.

Cite This Study

Abhay Singh (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3d9https://doi.org/10.1182/blood-2025-4637
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  3. 3Lymphoma are the most frequent secondary hematologic malignancies following solid tumors: A large cohort study from the german cancer registry nrw2025
  4. 4Sex-stratified risk of second malignancies in Hodgkin lymphoma survivors: A SEER-based analysis of latency and cancer type.2025
  5. 5Secondary cancer risks after breast radiotherapy: A dose-response-based comparative review across modern techniques2025 · 2 citations