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October 12, 2025The OncologistOpen Access

The risk of Radiation-Associated second cancer in patients with cervical cancer following radiotherapy from 1975-2019

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Authors

SWShanshan WangXYXiaojing YangZGZhongrong Gao

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Overview

Analysis reveals risk of radiation-associated second primary malignancies in cervical cancer patients, indicating a decline over decades.

Key Points

  • The study found that external beam radiation therapy was associated with a 2.13-fold increased risk of pelvic SPMs.
  • Cumulative incidence of pelvic SPMs significantly decreased from 3.92% to 2.27% over the studied years, indicating improvement in outcomes.
  • Brachytherapy alone raised pelvic SPM risk with a 3.04 sHR, but its combination with EBRT did not further elevate the risk.
  • The findings support improved safety in radiotherapy techniques for cervical cancer patients over the last four decades.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdaeaehttps://doi.org/10.1093/oncolo/oyaf334
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proportion of second hematologic malignancies linked to radiotherapy treatment in adults: A cohort study in the US SEER cancer registries 2001-20222025
  2. 2Subsequent primary cancer incidence in cervical cancer survivors: insights from a comprehensive cohort study utilizing combined Japanese population-based cancer registries2025
  3. 3Comprehensive Analysis of Conditional Survival in Radiation-treated Patients With Gynecologic Malignancies Using the SEER Database2025
  4. 4Risk of second primary malignancies among CLL survivors across treatment eras: A SEER-based study with racial and ethnic stratification2025
  5. 5Secondary cancer risks after breast radiotherapy: A dose-response-based comparative review across modern techniques2025 · 2 citations