What question did this study set out to answer?

To investigate urine mRNA gene expression profiles related to kidney function in sickle cell disease.

December 8, 2025BloodOpen Access

Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy

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Urine mRNA profiles reveal biomarkers of nephron injury in sickle cell disease, indicating links to hypertension.

To investigate urine mRNA gene expression profiles related to kidney function in sickle cell disease.
Collected urine samples from 50 adults with sickle cell disease.
Isolated mRNA and performed real time PCR to analyze nephron segment biomarkers.
Assessed correlations between mRNA expression and clinical markers of kidney dysfunction.
Increased expression of AQP2 and NPHS1 linked to kidney dysfunction and hypertension.
Expression levels correlated with age and blood pressure measurements.
54% of participants had chronic kidney disease, with significant biomarkers identified.

Ruiz et al. (2025) studied this question.

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