August 14, 2025Open Access

Urinary proteins from Sickle Cell patients induce inflammation and kidney injury via the TGFβ-p53 axis in a podocyte cell culture model

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Analysis shows kidney injury markers elevate inflammation in sickle cell patients, highlighting proteinuria's impact on kidney health.

Sickle cell disease with proteinuria elevated inflammation and kidney injury markers, particularly TGFβ and NGAL.
Kidney injury marker Clusterin was up-regulated in patients with proteinuria, validating its role in monitoring renal complications.
The study utilized a podocyte cell culture model to explore inflammatory responses to urinary proteins in sickle cell disease.
Findings suggest that proteinuria exacerbates kidney injury in sickle cell patients, pointing to the need for targeted therapies.

Wruck et al. (2025) studied this question.

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