Proteomic biomarker analysis reveals distinct protein profiles in chronic kidney disease, indicating underlying molecular heterogeneity.
Key Points
Distinct proteomic differences were found in chronic kidney disease patients with diabetic kidney disease, glomerulonephritis, and hypertensive nephropathy.
Diabetic kidney disease showed elevated levels of plexin B2, vascular adhesion protein-1, and kidney injury molecule-1, indicating immune activation and tubular damage.
An analysis of 2926 proteins was conducted using proteomic biomarker assessment in patients enrolled in the DAPA-CKD trial.
These findings suggest that molecular pathways differ significantly among the various etiologies of chronic kidney disease.